Dna Testing Strategies Aimed at Preventing Hereditary Non-polyposis Colon Cancer (hnpcc)
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چکیده
l et al et al ) ) 2003, there were 147,500 new diagnoses and 57,100 deaths involving colorectal cancer. rectal cancer is the third most common cancer type and the third most common cause of cancer death in both men and women (American Cancer Society, 2003). 200 of every 1,000 diagnosed colorectal cancer cases wil be familial, meaning that a relative will also have colorecta cancer (Trimbath and Giardiello, 2002). Of these 200 familial cases, about 40 will be explained by HNPCC. This is the most common Mendelian form of colorectal
منابع مشابه
Molecular Analysis of Microsatellite Instability in Hereditary Non Polyposis Colon Carcinoma Patients from North-East Iran
Background and Objectives: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by germ-line mutations in DNA mismatch repair genes. Tumors arising as a result of these mutations display instability in a sequence area known as microsatellites. Studies have shown that some Bethesda markers (BAT25, BAT26) are more efficient than other...
متن کاملHereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies
Introduction: Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is an autosomal dominant genetic disease. The disease is caused by a mutation in one of four genes of the DNA mismatch repair system and increases the risk for various cancers, especially the uterine and colon cancers. The prevalence of this disease in the general population is about 1 in 500 and it causes about 2-3...
متن کاملMutation screening of MSH2 and MLH1 mRNA in hereditary non-polyposis colon cancer syndrome.
Germline mutations in four human mismatch repair genes (MSH2, MLH1, PMS1, and PMS2) have been reported to cause hereditary non-polyposis colon cancer syndrome (HNPCC). The identification of germline mutations in HNPCC kindreds allows precise diagnosis and accurate predictive testing. To investigate further the genetic epidemiology of HNPCC and the nature and frequency of germline mutations in t...
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Hereditary non-polyposis colorectal cancer (HNPCC) is a very important clinical entity in oncology. In order to identify HNPCC, the international diagnostic criteria named "Amsterdam criteria" have been used. In this report, we present a case of an HNPCC patient who met the revised Amsterdam criteria after the sequential history taking in which a novel germline mutation of hMSH2 gene was detect...
متن کاملPrevention of early-onset familial/hereditary colon cancer: new models and mechanistic biomarkers (review).
Human colon cancer is a multi-factorial, multi-step disease wherein genetic and dietary factors represent important regulators of initiation, promotion and progression. While the etiology of sporadic colon cancer remains largely unidentified, familial adenomatous polyposis (FAP) and hereditary non-polyposis colon cancer (HNPCC) represent predisposing genetic syndromes for early-onset familial/h...
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تاریخ انتشار 2004